Nf-κB proteins are characterized by the presence of a 300-amino acid sequence on the N-terminus called the Rel homology domain (RHD). Five members comprise the Nf-κB protein family: RelA/p65, RelB, c-Rel, p50 ａnd p52. These proteins bind to kB sites as homo- or hetero- dimers which can have a positive or negative impact on gene transcription.
There are two types of Nf-κB signaling pathway: canonical ａnd non-canonical. Both require activation through post translational modifications of IkB inhibitors. Canonical pathway activation predominantly occurs through BCR, TCR, TLR4, IL-1R or TNF-R receptors, whereas the non-canonical pathway involves receptor activation of CD40L, BAFF or lymphotoxin-B.
Nf-κB蛋白質(zhì)的特征在于在N-末端存在稱為Rel同源性結(jié)構(gòu)域（RHD）的300個(gè)氨基酸的序列。Nf-κB蛋白家族由五個(gè)成員組成：RelA / p65，RelB，c-Rel，p50和p52。這些蛋白作為同源或異源二聚體結(jié)合到kB位點(diǎn)上，可能對(duì)基因轉(zhuǎn)錄產(chǎn)生正面的或負(fù)面的影響。
Nf-κB信號(hào)傳導(dǎo)途徑有兩種類型：典型和非典型。兩者都需要通過IkB抑制劑的翻譯后修飾來激活。典型途徑活化主要通過BCR，TCR，TLR4，IL-1R或TNF-R受體發(fā)生，而非經(jīng)典途徑涉及CD40L，BAFF或淋巴毒素-B的受體活化。
Helping your research
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Biorbyt擁有廣泛的小分子，可用作研究試劑以靶向NF-κB通路中的蛋白質(zhì)。我們提供最好的服務(wù)和簡單的購買流程，讓您專注于您的寶貴研究。看看我們的產(chǎn)品頁面，您可以找到具有競爭力的價(jià)格，交貨期和易于交付的選項(xiàng)。如果您有任何問題，請(qǐng)聯(lián)系我們。
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