標題PSMB8 Antibody (N-term) Catalog Number：OM218916

提供者：上海篤瑪生物科技有限公司發(fā)布時間：2024/9/27 閱讀次數(shù)：63次 >>進入該公司展臺

Product Name	PSMB8 Antibody (N-term)
Antibody Type	Primary Antibodies

Gene Synonyms	LMP7 PSMB5i RING10 Y2 More
Alternative Names	PSMB8 LMP7 PSMB5i RING10 Y2 Proteasome subunit beta type-8 Low molecular mass protein 7 Macropain subunit C13 Multicatalytic endopeptidase complex subunit C13 Proteasome component C13 Proteasome subunit beta-5i Really interesting new gene 10 pro More
Molecular Weight(MW)	30354 Da
Function	The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, ａnd Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. Replacement of PSMB5 by PSMB8 increases the capacity of the immunoproteasome to cleave model peptides after hydrophobic ａnd basic residues. Acts as a major component of interferon gamma-induced sensitivity. Plays a key role in apoptosis via the degradation of the apoptotic inhibitor MCL1. May be involved in the inflammatory response pathway. In cancer cells, substitution of isoform 1 (E2) by isoform 2 (E1) results in immunoproteasome deficiency. Required for the differentiation of preadipocytes into adipocytes More
Tissue Specificity	This PSMB8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 7-36 amino acids from the N-terminal region of human PSMB8.
Cellular Localization	Cylasm (By similarity). Nucleus (By similarity)

Entrez Gene	5696
Nucleotide Accession	NP_004150.1;NP_683720.2

Application

PSMB8 Antibody (N-term) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the PSMB8 antibody detected the PSMB8 protein (arrow).
Application

PSMB8 Antibody (N-term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

Application Notes	WB~~1:100~500 FC~~1:10~50:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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