標(biāo)題Anti-PSMB8 antibody Catalog Number：OM642612

提供者：上海篤瑪生物科技有限公司發(fā)布時間：2024/9/27 閱讀次數(shù)：47次 >>進(jìn)入該公司展臺

Gene Symbol	PSMB8
Gene Synonyms	JMP ALDD LMP7 NKJO D6S216 PRAAS1 PSMB5i RING10 D6S216E More
Gene Full Name	proteasome 20S subunit beta 8
Gene Summary	The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits ａnd 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration ａnd cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon ａnd this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq, Jul 2008] More
Molecular Weight(MW)	30kD(Observed:45 kD）
Cellular Localization	Cylasm, Nucleus, Proteasome

WB

Western blot analysis using PSMB8 antibody against HEK293(1), Hela(2), NiH3T3(3) cell lysate.
IHC

Immunohistochemical analysis of paraffin-embedded colon cancer tissues using Interleukin 1 beta antibody with DAB staining.
ICC/IF

Immunofluorescence analysis of A549 cells using PSMB8 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes	WB:1:200-1:2000 IHC:1:200-1:2000 ICC/IF:1:100-1:500

Form	Liquid
Storage Instructions	Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer	Purified antibody in PBS with 0.05% sodium azide.

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