Background

Mammalian PTPases can be subdivided into two broad categories: transmembrane receptor PTPases ａnd intracellular PTPases. SHP-2 (PTPN11) is one of the 2 closely related mammalian intracellular PTPases whose sequences encode 2 tandem SRC homology 2 (SH2) domains located at the N-terminal side ａnd a single PTPase catalytic domain at C-terminus. In the inactive state, the N-terminal SH2 domain interacts with the PTP catalytic domain ａnd blocks access of potential substrates to the active site. Upon binding to target phospho-tyrosyl residues, the N-terminal SH2 domain is released from the PTP domain, ａnd the enzyme is activated by relieving this autoinhibition. SHP-2 is widely expressed in most tissues ａnd plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, ａnd cell migration.

Synonym(s)

SHP2, CFC, NS1, BPTP3, PTP2C, PTP-1D, SH-PTP2, SH-PTP3, MGC14433, SH2, SH 2, SH-2, SHP, shp

 

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