標(biāo)題SUMO2/3 Antibody (N-term) Catalog Number：OM222304

提供者：上海篤瑪生物科技有限公司發(fā)布時(shí)間：2024/9/30 閱讀次數(shù)：66次 >>進(jìn)入該公司展臺(tái)

Product Name	SUMO2/3 Antibody (N-term)
Antibody Type	Primary Antibodies

Gene Synonyms	SMT3A SMT3H2
Alternative Names	SUMO2 SMT3A SMT3H2 Small ubiquitin-related modifier 2 HSMT3 SMT3 homolog 2 SUMO-3 Sentrin-2 Ubiquitin-like protein SMT3A More
Molecular Weight(MW)	10871 Da
Function	Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 ａnd linkage to the E2 enzyme UBE2I, ａnd can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication ａnd repair, mitosis ａnd signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins More
Tissue Specificity	Broadly expressed.
Cellular Localization	Nucleus. Note=Nuclear bodies.

Entrez Gene	6613

Application

Western blot analysis of anti-SUMO2/3 N-term polyclonal antibody in 293 cell lysate. Sumo2/3 (arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Application

Western blot analysis of SUMO2/3 (arrow) using rabbit polyclonal SUMO2/3 Antibody (M1) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SUMO2/3 gene.

Application Notes	WB~~1:100~500:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high ａnd low pH buffers ａnd neutralized immediately, followed by dialysis against PBS.

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