WB~~1:500~5000 IHC~~1:250~500:

EMT
LYK

ITK
EMT
LYK
Tyrosine-protein kinase ITK/TSK
T-cell-specific kinase
Tyrosine-protein kinase Lyk
Kinase EMT

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function ａnd differentiation of conventional T-cells ａnd nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK Phosphorylation leads to ITK auhosphorylation ａnd full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase ａnd subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cylasm ａnd the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein ａnd LCP2. Then, a large number of signaling molecules such as VAV1 are recruited ａnd ultimately lead to lymphokine production, T-cell proliferation ａnd differentiation

WB~~1:500~5000 IHC~~1:250~500: