標題MCM2 Antibody (C-term) Catalog Number：OM213423

提供者：上海篤瑪生物科技有限公司發(fā)布時間：2024/9/27 閱讀次數(shù)：49次 >>進入該公司展臺

Product Name	MCM2 Antibody (C-term)
Antibody Type	Primary Antibodies

Gene Synonyms	BM28 CCNL1 CDCL1 KIAA0030 More
Alternative Names	MCM2 BM28 CCNL1 CDCL1 KIAA0030 DNA replication licensing factor MCM2 Minichromosome maintenance protein 2 homolog Nuclear protein BM28 More
Molecular Weight(MW)	101896 Da
Function	Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ＇once per cell cycle＇ DNA replication initiation ａnd elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase ａnd for cell division More
Tissue Specificity	This MCM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 656~685 amino acids from the C-terminal region of human MCM2.
Cellular Localization	Nucleus.

Entrez Gene	4171

Application

Western blot analysis of MCM2 Antibody (C-term) in HL-60 cell line lysates (35ug/lane). MCM2 (arrow) was detected using the purified Pab.
Application

MCM2 Antibody (C-term) immunohistochemistry analysis in formalin fixed ａnd paraffin embedded human colon carcinoma followed by peroxidase conjugation of the secondary antibody ａnd DAB staining. This data demonstrates the use of the MCM2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Application Notes	WB~~1:100~500 IHC~~1:50~100:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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