標(biāo)題MBP Antibody Catalog Number：OM213383

提供者：上海篤瑪生物科技有限公司發(fā)布時(shí)間：2024/9/25 閱讀次數(shù)：39次 >>進(jìn)入該公司展臺(tái)

Product Name	MBP Antibody
Antibody Type	Primary Antibodies

Alternative Names	MBP Myelin basic protein Myelin A1 protein Myelin membrane encephalitogenic protein More
Molecular Weight(MW)	33117 Da
Function	The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation ａnd stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, ａnd may also be involved in signaling pathways in T- cells ａnd neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation More
Tissue Specificity	MBP isoforms are found in both the central ａnd the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen ａnd spinal cord, as well as in cell lines derived from the immune system
Cellular Localization	Myelin membrane; Peripheral membrane protein; Cylasmic side. Note=Cylasmic side of myelin

Entrez Gene	4155

Application

A.Western blot analysis on fetal brain using anti-MBP RabMAb (Cat. #AJ1462a), dilution 1:5000.
Application

B. Immunocytochemistry analysis of PC12 cells using anti-MBP RabMAb (Cat. #AJ1462a).

Application Notes	WB~~1:500:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide ａnd 0.05% BSA.

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