標(biāo)題BMI1 Antibody Catalog Number：OM272571

提供者：上海篤瑪生物科技有限公司發(fā)布時(shí)間：2024/9/20 閱讀次數(shù)：41次 >>進(jìn)入該公司展臺

Product Name	BMI1 Antibody
Antibody Type	Primary Antibodies
Product description	BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling ａnd modification of histones; it mediates monoubiquitination of histone H2A ＇Lys-119＇, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.1) Smith, K.S., et al., Mol. Cell 12(2):393-400 (2003). Xia, Z.B., et al., Proc. Natl. Acad. Sci. U.S.A. 100(14):8342-8347 (2003). Itahana, K., et al., Mol. Cell. Biol. 23(1):389-401 (2003). Dimri, G.P., et al., Cancer Res. 62(16):4736-4745 (2002). Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000). More
Immunogen	This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.

Clonality	Polyclonal
Isotype	Ig
Host Species	Rabbit
Tested Applications	IHC-PWB
	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50:
Species Reactivity	Human
Concentration	1 mg/ml
Purification	Affinity purified

Gene Symbol	BMI1
Alternative Names	Polycomb complex protein BMI-1 Polycomb group RING finger protein 4 RING finger protein 51 BMI1 PCGF4 RNF51 More
Molecular Weight(MW)	37 kDa
Sequence Similarities	Predicted species reactivity based on immunogen sequence: Mouse

Entrez Gene	100532731 648
Protein Accession	P35226

Application

Western blot analysis in K562 cell line lysates (35ug/lane).
Application

Formalin-fixed ａnd paraffin-embedded human skeletal muscle reacted with BMI1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Application

Western blot analysis of BMI1 Antibody antibodyin 293 cell line lysates (35ug/lane)

Application Notes	For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50:

Form	Liquid
Storage Instructions	Store at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.

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