Neurofilaments are the 10nm or intermediate filament proteins specifically in neurons, ａnd are composed predominantly of three major proteins called NF- NF-M ａnd NF-H. NF-L is the neurofilament light or low molecular weight polypeptide ａnd runs on SDS-PAGE gels at about 68 kDa. Antibodies to NF-L are useful for identifying neuronal cells ａnd their processes in tissue sections ａnd in tissue culture. Mutations in the protein region of the human NF-L gene cause some forms of Charcot-Marie-Tooth disease.1) Harris, J., Ayyub, C. ａnd Shaw G. (1991) A molecular dissection of the carboxyterminal tails of the major neurofilament subunits NF-M ａnd NF-H. J Neurosci Res 30:47-62.
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Preparation of porcine intermediate filaments.

IHCWB

BovineChickenHumanMouseRat