標題NLRP3 Antibody (N-term) Catalog Number：OM215439

提供者：上海篤瑪生物科技有限公司發(fā)布時間：2024/8/30 閱讀次數(shù)：44次 >>進入該公司展臺

Product Name	NLRP3 Antibody (N-term)
Antibody Type	Primary Antibodies

Gene Synonyms	C1orf7 CIAS1 NALP3 PYPAF1 More
Alternative Names	NLRP3 C1orf7 CIAS1 NALP3 PYPAF1 NACHT LRR ａnd PYD domains-containing protein 3 Angiotensin/vasopressin receptor AII/AVP-like Caterpiller protein 1.1 Cold autoinflammatory syndrome 1 protein Cryopyrin PYRIN-containing APAF1-like protein 1 More
Molecular Weight(MW)	118173 Da
Function	May function as an inducer of apoptosis. Interacts selectively with ASC ａnd this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation ａnd nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing ａnd release of IL1B ａnd IL18 More
Tissue Specificity	Expressed in blood leukocytes. Strongly expressed in polymorphonuclear cells ａnd osteoblasts. Undetectable or expressed at a lower magnitude in B- ａnd T-lymphoblasts, respectively. High level of expression detected in chondrocytes Detected in non-keratinizing epithelia of oropharynx, esophagus ａnd ectocervix ａnd in the urothelial layer of the bladder
Cellular Localization	Cylasm.

Entrez Gene	114548

Application

Western blot analysis of NLRP3 Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane).NLRP3 (arrow) was detected using the purified Pab.
Application

NLRP3 Antibody (N-term) immunohistochemistry analysis in formalin fixed ａnd paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody ａnd DAB staining. This data demonstrates the use of the NLRP3 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.

Application Notes	WB~~1:100~500 IHC~~1:10~50:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

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