標(biāo)題BRCA1 (phospho Ser1423) antibody Catalog Number：OM241901

提供者：上海篤瑪生物科技有限公司發(fā)布時(shí)間：2024/8/23 閱讀次數(shù)：35次 >>進(jìn)入該公司展臺(tái)

Product Name	BRCA1 (phospho Ser1423) antibody
Antibody Type	Primary Antibodies
Product description	Rabbit Polyclonal antibody to BRCA1 (Phospho Ser1423)The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation More
Immunogen	Peptide sequence around phosphorylation site of serine 1423 (H-G-S(p)-Q-P) derived from Human BRCA1.

Clonality	Polyclonal
Host Species	Rabbit
Tested Applications	IHC-PWB
	Suggested starting dilutions are as follows. WB: 1:500~1:1000, IHC-P: 1:50~1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity	Human
Concentration	1 mg/ml (Please refer to the vial label for the specific concentration)
Purification	Affinity purified

Gene Synonyms	BRCAI BRCC1 BROVCA1 IRIS PNCA4 PSCP RNF53 BRCA1 breast cancer type 1 susceptibility protein RING finger protein 53 breast ａnd ovarian cancer sususceptibility protein 1 breast ａnd ovarian cancer susceptibility protein 1 protein phosphatase 1 re More
Target	BRCA1 (Phospho Ser1423)
Molecular Weight(MW)	220 (note)

Application

Western blot analysis of extracts from HT29 cells untreated or treated with Anisomycin using BRCA1(Phospho-Ser1423) Antibody
Application

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BRCA1 (Phospho-Ser1423) Antibody (left) or the same antibody preincubated with blocking peptide (right).
Application

Western blot analysis of extracts from HT29 cells untreated or treated with Anisomycin using BRCA1 (Phospho-Ser1423) Antibody .

Application Notes	Suggested starting dilutions are as follows. WB: 1:500~1:1000, IHC-P: 1:50~1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:

Form	Liquid
Storage Instructions	Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

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