Crohn＇s disease in patients with moderate to severe active ulcerative colitis, routine treatment or tumor necrosis factor α （TNF α） Antagonists can also be treated with vidolizumab. Vedolizumab is a humanized monoclonal therapeutic antibody, which selectively α four β Integrins bind to activated lymphocytes, preventing them from entering the intestinal mucosa. Vedolizumab attacks through TNF α The mechanism of action other than antagonists enters the inflammatory response ａnd inhibits gastrointestinal inflammation.

The efficacy of vedolizumab treatment is usually dose related. The therapeutic antibody administered in the patient＇s serum can detect the patient, namely the so-called valley level. Various factors affect the height of valley level. These include: disease activity, individual differences in pharmacokinetics, ａnd the emergence of anti drug antibodies (ADA).

Aimeijie Free Vitolimus McAb ADA Level Test Kit is used to determine free human antibody of Vitolimus McAb (such as ENTYVIO) ®)  Applicable to EDTA plasma ａnd serum. It is only used for in vitro diagnosis.

引言：

中度至重度活動(dòng)型潰瘍性結(jié)腸炎患者克羅恩病，常規(guī)治療或腫瘤壞死因子α（TNFα）拮抗劑也可以用維多利單抗治療。韋多利單抗是一種人源化單克隆治療抗體，它選擇性地將α4β7整合素與活化的淋巴細(xì)胞結(jié)合，從而阻止它們進(jìn)入腸粘膜。韋多利單抗攻擊通過TNFα拮抗劑以外的作用機(jī)制進(jìn)入炎癥反應(yīng)并抑制胃腸道炎癥。

維多利單抗治療的療效通常與劑量相關(guān)在患者血清中施用的治療抗體可以檢測(cè)到患者，即所謂的谷平面。各種因素影響著谷平面的高度。其中包括：疾病活動(dòng)、藥代動(dòng)力學(xué)中的個(gè)體差異和抗藥物抗體（ADA）的出現(xiàn)。

艾美捷游離維多珠單抗ADA水平檢測(cè)試劑盒用于測(cè)定維多利單抗（如ENTYVIO）的游離人抗體®) 適用于EDTA血漿和血清。

只用于體外診斷。

艾美捷游離維多珠單抗ADA水平檢測(cè)試劑盒基本參數(shù)：

中文名稱：游離維多珠單抗ADA水平檢測(cè)試劑盒

英文名字：lDKmonitor®Vedolizumab free ADA

編號(hào)：IDK-K9648

規(guī)格：96Tests、5/96Tests  

保存建議：置于2-8°C保存

艾美捷游離維多珠單抗ADA水平檢測(cè)試劑盒測(cè)試包的內(nèi)容：

Art.-Nr. Bezeichnung Kit-Komponenten Menge

K 9648 CTRL CUT OFF Cut-off-Kontrolle, lyophilisiert 4x 1 vial

K 9648 AB Detektionsantikörperkonzentrat

(Therapieantikörper, biotinyliert) 1x 200µl

K 9648 ASYBUF Assaypuffer, gebrauchsfertig 1x 50ml

K 0002.15 SUB Substrat (Tetramethylbenzidin),

gebrauchsfertig 1x 15ml

K 0003.15 STOP Splösung, gebrauchsfertig 1x 15ml

Für Nachbestellungen von Einzelkomponenten verwenden Sie als Bestellnummer die Artikelnummer gefolgt von der Bezeichnung.

來源：https://www.amyjet.com/products/IDK-K9648.shtml