CAS Registry No.: 1989-52-2

Formal Name: (3β)-cholest-5-en-3-ol 3-tetradecanoate

Synonyms: Cholesterol Myristate, Cholesteryl Tetradecanoate, Myristic Acid cholesteryl ester, NSC 226867

MF: C41H72O2

FW: 597.0

Purity: ≥98%

Supplied as: A crystalline solid

Storage: -20°C

Stability: ≥2 years

艾美捷膽固醇肉豆蔻酸酯實(shí)驗(yàn)室程序：

Cholesteryl myristate is supplied as a crystalline solid. A stock solution may be made by dissolving the cholesteryl myristate in the solvent of choice. Cholesteryl myristate is soluble in the organic solvent chloroform, which should be purged with an inert gas, at a concentration of approximately 10 mg/ml.

艾美捷膽固醇肉豆蔻酸酯相關(guān)描述：

Cholesteryl myristate is a cholesterol ester.1 Levels of cholesteryl myristate are increased in the serum, liver, ａnd aorta in rabbits fed a high-cholesterol diet ａnd positively correlate with development of non-alcoholic fatty liver disease (NAFLD). Plasma levels of cholesteryl myristate also positively correlate with the presence of unstable atherosclerotic plaques in coronary artery disease.2 Cholesterol myristate has been used in the composition of lipid nanoparticles (LNPs) as a drug carrier systems for drugs with low water solubility.3

文獻(xiàn)參考：

1.Kim, E.J., Kim, B.H., Seo, H.S., et al. Cholesterol-induced non-alcoholic fatty liver disease ａnd atherosclerosis aggravated by systemic inflammation. PLoS One 5(6), e97841 (2014).

2.Meikle, P.J., Wong, G., Tsorotes, D., et al. Plasma lipidomic analysis of stable ａnd unstable coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 31(11), 2723-2732 (2011).

3.Rosenblatt, K.M. ａnd Bunjes, H. Evaluation of the drug loading capacity of different lipid nanoparticle dispersions by passive drug loading. Eur. J. Pharm. Biopharm. 117, 49-59 (2017).

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