【英語名稱】：Chk2 (phospho Thr68) Polyclonal Antibody

【產(chǎn)品類型】：一抗

【供應商】：Abbkine

【產(chǎn)品貨號】：ABP50289

【產(chǎn)品規(guī)格】：30ul/100ul/200ul

【背景資料】：In response to DNA damage ａnd replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. Checkpoint kinase 2 encoded by CHEK2 is a cell cycle checkpoint regulator ａnd putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage ａnd is rapidly phosphorylated in response to replication blocks ａnd DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, ａnd has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, Checkpoint kinase 2 interacts with ａnd phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, ａnd brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for CHEK2..
蛋白別名為：CHEK2; CDS1; CHK2; RAD53; Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2;基因ID為：11200；蛋白質(zhì)ID:O96017

【應用類型】：WB，IHC-p，ELISA
補充：*優(yōu)的抗體稀釋比例需要基于客戶實驗進行優(yōu)化.建議的起始稀釋比例如下: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:20000. Not yet tested in other applications.

【免疫原】：合成多肽：human Chk2 around the phosphorylation site of T68.

【來源宿主】：兔

【反應性】：人，小鼠，大鼠

【保存建議】：廠家推薦藍冰運輸.在發(fā)貨后能在-20℃保存1年.為限度的避免損失，請在打開管蓋之前融化抗體并離心.我們建議使用前分裝以避免反復凍融.
本產(chǎn)品為液體形式,溶解于PBS緩沖液中，含50%甘油，0.5%BSA和0.02%疊氮化鈉.

【產(chǎn)品說明】：點擊：細胞周期檢測點激酶2(phospho Thr68) 多克隆抗體查看更詳細產(chǎn)品說明，更多應用、儲存、價格、貨期等信息請致電垂詢Abbkine中國區(qū)域授權(quán)總代理艾美捷科技有限公司。更多特色試劑盒、特色抗體以及特色試劑等產(chǎn)品評論，請點擊查看每日生物評論網(wǎng)站。

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產(chǎn)品標簽:細胞周期檢測點激酶2(phospho Thr68)，細胞周期檢測點激酶2(phospho Thr68)ABP50289，Chk1 Polyclonal Antibody，細胞周期檢測點激酶2(phospho Thr68) 多克隆抗體,Chk2 (phospho Thr68) Polyclonal Antibody