產(chǎn)品展示
Peprotech Recombinant Human IL-12細胞因子報價
點擊次數(shù)：35發(fā)布時間：2016/1/26 14:14:29
更新日期：2016/1/26 14:14:29
所 在 地：中國大陸
產(chǎn)品型號：200-12
優(yōu)質(zhì)供應
詳細內(nèi)容
產(chǎn)品編號:
200-12
別名:
NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, IL-12p70
描述:
IL-12 is a potent regulator of cell-mediated immune responses ａnd it induces IFN-γ production by NK ａnd T cells. It is produced by activated monocytes/macrophage cells, B lymphocytes ａnd connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth ａnd activity of activated NK, CD4+ ａnd CD8+ cells, ａnd induces the development of IFN-γ-producing Th1 cells. Recombinant Human IL-12 is a 75.0 kDa heterodimeric glycoprotein consisting of disulfide-linked 35 kDa (p35) ａnd 40 kDa (p40) subunits (503 total amino acid residues).
氨基酸序列:
p35 Subunit: RNLPVA TPDPGMFPCL HHSQNLLRAV SNMLQKARQT LEFYPCTSEE IDHEDITKDK TSTVEACLPL ELTKNESCLN SRETSFITNG SCLASRKTSF MMALCLSSIY EDLKMYQVEF KTMNAKLLMD PKRQIFLDQN MLAVIDELMQ ALNFNSETVP QKSSLEEPDF YKTKIKLCIL LHAFRIRAVT IDRVMSYLNA S
p40 Subunit: IWELKK DVYVVELDWY PDAPGEMVVL TCDTPEEDGI TWTLDQSSEV LGSGKTLTIQ VKEFGDAGQY TCHKGGEVLS HSLLLLHKKE DGIWSTDILK DQKEPKNKTF LRCEAKNYSG RFTCWWLTTI STDLTFSVKS SRGSSDPQGV TCGAATLSAE RVRGDNKEYE YSVECQEDSA CPAAEESLPI EVMVDAVHKL KYENYTSSFF IRDIIKPDPP KNLQLKPLKN SRQVEVSWEY PDTWSTPHSY FSLTFCVQVQ GKSKREKKDR VFTDKTSATV ICRKNASISV RAQDRYYSSS WSEWASVPCS
來源:
CHO cells
純度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 was determined by the induction of IFN-γ from NK cells co-stimulated with IL-18 is ≤ 1.0 ng/ml, corresponding to a specific activity of ≥ 1 x 106units/mg.
交叉反應:
Bacteria, Monkey, Mouse, Human, Leech, Human + Mouse
研究領域:
原產(chǎn)國:
USA
僅用于研究。不適用于診斷或治療。
