產(chǎn)品展示
Recombinant Murine IL-6 Peprotech新品促銷
點(diǎn)擊次數(shù)：36發(fā)布時(shí)間：2016/1/26 14:02:21
更新日期：2016/1/26 14:02:21
所 在 地：中國大陸
產(chǎn)品型號：216-16
優(yōu)質(zhì)供應(yīng)
詳細(xì)內(nèi)容
產(chǎn)品編號:
216-16
別名:
26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2
描述:
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune ａnd inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells ａnd keratinocytes, IL-6 has diverse biological functions. It stimulates B cell differentiation ａnd antibody production, synergizes with IL-3 in megakaryocyte development ａnd platelet production, induces expression of hepatic acute-phase proteins, ａnd regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α ａnd gp130. Murine IL-6 is inactive on human cells, while both human ａnd murine are equally active on murine cells. Recombinant Murine IL-6 is a 21.7 kDa protein containing 188 amino acid residues.
氨基酸序列:
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
來源:
E.coli
純度:
Greater than 98% by SDS-PAGE gel ａnd HPLC analyses.
生物活性:
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is ≤ 0.02 ng/ml, corresponding to a specific activity of ≥ 5 x 107 units/mg.
交叉反應(yīng):
Monkey, Mouse, Trout, Rat, Mouse + Bacteria, Human + Mouse, Mouse + Virus
研究領(lǐng)域:
 | 血管生成/ 心血管 |  | 癌癥 |
 | 細(xì)胞培養(yǎng) |  | 糖尿病/ 體重調(diào)節(jié) |
 | 免疫系統(tǒng) |  | 炎癥 |
 | 神經(jīng)生物學(xué) |  | 干細(xì)胞及分化 |
 | 創(chuàng)傷修復(fù) |  | 過敏 |
 | 移植 | ||
原產(chǎn)國:
USA
僅用于研究。不適用于診斷或治療。
