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P-V-Myb+C-Myb(S11) [SZ04-81] Catalog Number：OM637105

點(diǎn)擊次數(shù)：39 發(fā)布時(shí)間：2024/9/30 14:52:58
 

Product Profile

Product Name P-V-Myb+C-Myb(S11) [SZ04-81]
Antibody Type Primary Antibodies
Product description 
The Myb family of transcription factors regulates proliferation, differentiation ａnd apoptosis of hemaoletic cells. The avian myeloblastosis viral (v-Myb) protein is nuclear ａnd binds to specific DNA sequences. The gene encoding for v-Myb is oncogenic, causing monoblastic leukemia ａnd transforming myelomonocytic cells by deregulating the expression of specific target genes. v-Myb functions as a transcriptional activator, ａnd it can repress biologically relevant genes such as Ets-2, which promotes macrophage differentiation. The proto-oncogene c-Myb encodes for a nuclear protein that plays a role in transcriptional regulation ａnd may be essential for hemaoietic cell proliferation. A-Myb is also member of the Myb family that is expressed in proliferating B cell centroblasts. Transgenic mice overexpressing A-Myb posses enhanced hyperplasia of the lymph nodes.
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Immunogen 
Synthetic phospho-peptide corresponding to residues surrounding Ser11 of human V-Myb+C-Myb.

Key Feature

Clonality Monoclonal
Isotype IgG
Host Species Recombinant rabbit
Tested Applications

WBICC/IFIHCFC
 
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
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Species Reactivity

Human
Concentration 1 mg/mL.

Target Information

Alternative Names
C myb antibody C myb protein antibody Cmyb antibody MYB antibody Myb proto oncogene antibody V myb myeloblastosis viral oncogene homolog antibody
Molecular Weight(MW) 72/75 kDa
Cellular Localization Nucleus.

Database Links

SwissProt ID P10242

Application

  • Application

    Fig1: ICC staining P-V-Myb+C-Myb(S11) in Ags cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig2: Immunohistochemical analysis of paraffin-embedded human uterine neck tissue using anti-P-V-Myb+C-Myb(S11) antibody. Counter stained with hematoxylin.

  • Application

    Fig3: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using anti-P-V-Myb+C-Myb(S11) antibody. Counter stained with hematoxylin.

  • Application

    Fig4: Flow cytometric analysis of MCF-7 cells with P-V-Myb+C-Myb(S11) antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as antibody

Positive Control Ags, human uterine neck tissue, human breast carcinoma tissue.
Application Notes
WB:1:1,000-1:2,000
ICC:1:50-1:200
IHC:1:50-1:200
FC:1:50-1:100
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Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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