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PSMB8 [H2-A5] Catalog Number:OM627709

點擊次數(shù):46 發(fā)布時間:2024/9/27 15:05:27
 

Product Profile

Product Name PSMB8 [H2-A5]
Antibody Type Primary Antibodies
Product description
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit.
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Immunogen
Recombinant protein

Key Feature

Clonality Monoclonal
Isotype IgG1
Host Species Mouse
Tested Applications

WBICCIHC

 
WB:1:500-1:2,000
ICC:1:100-1:500
IHC:1:100-1:500
Species Reactivity

HumanRat

Concentration 2 mg/mL.

Target Information

Alternative Names
ALDD antibody D6S216 antibody D6S216E antibodyLarge multifunctional peptidase 7 antibody Large multifunctional protease 7 antibody LMP 7 antibody LMP7 antibody Low molecular mass protein 7 antibody Low molecular weight protein 7 antibody Macropain subunit C13 antibody MGC1491 antibody Multicatalytic endopeptidase complex subunit C13 antibody NKJO antibody OTTHUMP00000062981 antibody Protease component C13 antibody Proteasome (prosome macropain) subunit beta type 8 antibody Proteasome (prosome
macropain) subunit
beta type
8 (large multifunctional peptidase 7) antibody Proteasome beta 8 subunit antibody Proteasome catalytic subunit 3i antibody Proteasome component C13 antibody Proteasome related gene 7 antibody Proteasome subunit beta 5i antibody Proteasome subunit beta 8 antibody Proteasome subunit beta type 8 antibody Proteasome subunit beta type antibody Proteasome subunit beta type-8 antibody Proteasome subunit beta-5i antibody Proteasome subunit Y2 antibody PSB8_HUMAN antibody PSMB 8 antibody PSMB5i antibody PSMB8 antibody Really interesting new gene 10 protein antibody RING 10 antibody RING10 antibody Y2 antibody
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Molecular Weight(MW) 22 kDa
Cellular Localization Cylasm. Nucleus.

Database Links

SwissProt ID P28062
P28064

Application

  • Application

    Fig1: Western blot analysis of PSMB8 on human PSMB8 recombinant protein using anti-PSMB8 antibody at 1/1,000 dilution.

  • Application

    Fig2: Western blot analysis of PSMB8 on different cell lysates using anti-PSMB8 antibody at 1/1,000 dilution. Positive control: Lane 1: Hela Lane 2: MCF-7 Lane 3: A431 Lane 4: RAJI Lane 5: MOTL4 Lane 6: PC-12

  • Application

    Fig3: ICC staining PSMB8 (green) and actin filaments (red) in Hela cells. The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig4: Immunohistochemical analysis of paraffin-embedded intima cancer tissue using anti-PSMB8 antibody. Counter stained with hematoxylin.

  • Application

    Fig5: Immunohistochemical analysis of paraffin-embedded human colon tissue using anti-PSMB8 antibody. Counter stained with hematoxylin.

Application Notes
WB:1:500-1:2,000
ICC:1:100-1:500
IHC:1:100-1:500

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

原創(chuàng)作者:上海篤瑪生物科技有限公司

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