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聯(lián)系人：楊燕燕
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技術文章
Anti-MBP antibody Catalog Number：OM642617
點擊次數(shù)：36 發(fā)布時間：2024/9/25 14:52:10
Product Profile
| Product Name | Anti-MBP antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ICC/IFWB |
| WB:1:200-1:2000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | MBP |
|---|---|
| Gene Full Name | myelin basic protein |
| Gene Summary | The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes ａnd Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow ａnd the immune system. These mRNAs arise from the long MBP gene (otherwise called "Golli-MBP") that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli ａnd the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts ａnd gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons ａnd produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit ａnd that this arrangement is important for the function and/or regulation of these genes. [provided by RefSeq, Jul 2008] More |
| Molecular Weight(MW) | 33kD(Observed:55 kD) |
| Cellular Localization | Cell membrane, Membrane, Nucleus |
Application
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WB
Western blot analysis using MBP antibody against NIH3T3(1) cell lysate.
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ICC/IF
Immunofluorescence analysis of MG-63 cells using MBP antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | WB:1:200-1:2000 ICC/IF:1:100-1:500 |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
