欧美三级欧美成人高清,麻豆网神马久久人鬼片,男同gay自慰网站,欧美日韩精品一区二区三区激情,在线,男人的天堂av

企業(yè)檔案

  • 會(huì)員類型：免費(fèi)會(huì)員
  • 工商認(rèn)證： 【已認(rèn)證】
  • 最后認(rèn)證時(shí)間：
  • 法人：
  • 注冊(cè)號(hào)：
  • 企業(yè)類型：生產(chǎn)商
  • 注冊(cè)資金：人民幣萬(wàn)

聯(lián)系我們

聯(lián)系人：楊燕燕

點(diǎn)擊查看聯(lián)系方式

技術(shù)文章

NQO1 Antibody (H-90) AC Catalog Number：OM168082

點(diǎn)擊次數(shù)：32 發(fā)布時(shí)間：2024/9/25 14:45:14
 

Product Profile

Product Name NQO1 Antibody (H-90) AC
Antibody Type Primary Antibodies
Modification Notes NAD(P)H:qui oxidoreductase 1 (NQO1) ａnd NRH:qui oxidoreductase (NQO2) are flavoproteins that catalyze the metabolic detoxification of quis ａnd their derivatives to hydroquis, using either NADH or NADPH as the electron donor (1-3). This protects cells against qui-induced oxidative stress, cytotoxicity, ａnd mutagenicity (1). Many tumors overexpress NQO1, which is an obligate two-electron reductase that deactivates toxins ａnd activates bioreductive anticancer drugs (4). NQO1, a 274 amino acid protein, is ubiquitously expressed, but the expression level varies among tissues. NQO1 gene expression is coordinately induced in response to xenobiotics, antioxidants, heavy metals ａnd radiation. The antioxidant response element (ARE) in the NQO1 gene promoter is essential for expression ａnd coordinated induction of NQO1. ARE activation by tert-butylhydroqui is dependent on PI3-kinase, which lies upstream of Nrf2 (5). Nrf2, c-Jun, Nrf1, Jun-B ａnd Jun-D bind to the ARE ａnd regulate expression ａnd induction of NQO1 gene. Maf-Maf homodimers ａnd possibly Maf-Nrf2 heterodimers play a role in negative regulation of ARE-mediated transcription, but Maf-Nrf1 heterodimers fail to bind with the NQO1 gene ARE ａnd do not repress NQO1 transcription (6-7).

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

WBIPIFELISA
 
recommended for detection of NQO1 of mouse, rat ａnd human origin by WB, IP, IF ａnd ELISA; also reactive with additional species, including canine, bovine ａnd porcine:
Species Reactivity

HumanMouseRat
Concentration 1mg/ml
Purification Affinity purified

Target Information

Alternative Names
epie corresponding to amino acids 185-274 mapping at the C-terminus of NQO1 of human origin
Tissue Specificity epie corresponding to amino acids 185-274 mapping at the C-terminus of NQO1 of human origin

Database Links

Entrez Gene 1728

Application

  • Application

    Immunofluorescence staining of normal mouse intestine frozen section showing cylasmic staining.

  • Application

    Western blot analysis of NQO1 expression in Hep G2 whole cell lysate.

  • Application

    Immunofluorescence staining of methanol-fixed Hep G2 cells showing cylasmic localization.

Application Notes
recommended for detection of NQO1 of mouse, rat ａnd human origin by WB, IP, IF ａnd ELISA; also reactive with additional species, including canine, bovine ａnd porcine:

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

相關(guān)產(chǎn)品

script>