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技術(shù)文章

Anti-PPP1CA antibody Catalog Number:OM642619

點(diǎn)擊次數(shù):31 發(fā)布時(shí)間:2024/9/24 14:23:55
 

Product Profile

Product Name Anti-PPP1CA antibody
Antibody Type Primary Antibodies
Immunogen
Polypeptide

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ELISAICC/IFIHC

 
IHC:1:200-1:2000
ICC/IF:1:100-1:500
Species Reactivity

HumanMouseRat

Concentration 1mg/ml
Purification Protein A

Target Information

Gene Symbol PPP1CA
Gene Synonyms
PP1A
PP-1A
PPP1A
PP1alpha
More 
Gene Full Name protein phosphatase 1 catalytic subunit alpha
Gene Summary
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). This broadly expressed gene encodes the alpha subunit of the PP1 complex that associates with over 200 regulatory proteins to form holoenzymes which dephosphorylate their biological targets with high specificity. PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies suggest that PP1 is an important regulator of cardiac function and that PP1 deregulation is implicated in diabetes and multiple types of cancer. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2020]
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Molecular Weight(MW) 38KD
Cellular Localization Cylasm, Nucleus

Application

  • IHC

    Immunohistochemical analysis of paraffin-embedded lung cancer tissues using PPP1CA antibody with DAB staining.

  • IHC

    Immunohistochemical analysis of paraffin-embedded breast cancer tissues using PPP1CA antibody with DAB staining.

  • ICC/F

    Immunofluorescence analysis of A549 cells using PPP1CA antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.

Application Notes
IHC:1:200-1:2000
ICC/IF:1:100-1:500

Additional Information

Form Liquid
Storage Instructions Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer Purified antibody in PBS with 0.05% sodium azide.

原創(chuàng)作者:上海篤瑪生物科技有限公司

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