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技術(shù)文章

BMI1 Antibody Catalog Number：OM272571

點(diǎn)擊次數(shù)：40 發(fā)布時(shí)間：2024/9/20 15:39:56
 

Product Profile

Product Name BMI1 Antibody
Antibody Type Primary Antibodies
Product description 
BMI is a component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling ａnd modification of histones; it mediates monoubiquitination of histone H2A ＇Lys-119＇, rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin ligase activity of RNF2/RING2. BMI cooperates with the MYC oncogene to produce B-lymphomas.1) Smith, K.S., et al., Mol. Cell 12(2):393-400 (2003). Xia, Z.B., et al., Proc. Natl. Acad. Sci. U.S.A. 100(14):8342-8347 (2003). Itahana, K., et al., Mol. Cell. Biol. 23(1):389-401 (2003). Dimri, G.P., et al., Cancer Res. 62(16):4736-4745 (2002). Bardos, J.I., et al., J. Biol. Chem. 275(37):28785-28792 (2000).
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Immunogen 
This BMI1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 257-286 amino acids from the C-terminal region of human BMI1.

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

IHC-PWB
 
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol BMI1
Alternative Names
Polycomb complex protein BMI-1
Polycomb group RING finger protein 4
RING finger protein 51
BMI1
PCGF4
RNF51
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Molecular Weight(MW) 37 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Mouse

Database Links

Entrez Gene 100532731
 648
Protein Accession P35226

Application

  • Application

    Western blot analysis in K562 cell line lysates (35ug/lane).

  • Application

    Formalin-fixed ａnd paraffin-embedded human skeletal muscle reacted with BMI1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.

  • Application

    Western blot analysis of BMI1 Antibody antibodyin 293 cell line lysates (35ug/lane)

Application Notes
For WB starting dilution is: 1:1000 For IHC-P starting dilution is: 1:10~50:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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