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技術(shù)文章

Gab1 Mutant Y659 Antibody Catalog Number：OM233629

點擊次數(shù)：43 發(fā)布時間：2024/9/14 13:55:57
 

Product Profile

Product Name Gab1 Mutant Y659 Antibody
Antibody Type Primary Antibodies

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

IHCDB
 
IHC~~1:50~100 DB~~1:100~500:
Species Reactivity

Human
Concentration 1 mg/ml
Purification  

Target Information

Alternative Names
GAB1
GRB2-associated-binding protein 1
GRB2-associated binder 1
Growth factor receptor bound protein 2-associated protein 1
More 
Molecular Weight(MW) 76616 Da
Function
Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) ａnd the insulin receptor (INSR)
Tissue Specificity This Gab1 Mutant Y659 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 645~675 amino acids surrounding Y659 of human GAB1 Y659.

Database Links

Entrez Gene 2549

Application

  • Application

    Formalin-fixed ａnd paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

  • Application

    Dot blot analysis of anti-hGab1-Y659H mutant Pab on nitrocellulose membrane. 50ng of Mutant-peptide or Non Mutant-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.

Application Notes
IHC~~1:50~100 DB~~1:100~500:

Additional Information

Form Liquid
Storage Instructions For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 

原創(chuàng)作者：上海篤瑪生物科技有限公司

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