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聯(lián)系人：楊燕燕
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技術(shù)文章
p-eIF4B Antibody (Ser 422) Catalog Number：OM184030
點擊次數(shù)：25 發(fā)布時間：2024/9/13 14:00:46
Product Profile
| Product Name | p-eIF4B Antibody (Ser 422) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The initiation of protein synthesis in eukaryotic cells is regulated by interactions between protein initiation factors ａnd RNA molecules. These interactions are facilitated, in part, by the eukaryotic initiation factor 4 family (eIF4) of proteins that are involved in the early initiation of protein synthesis. eIF4B (eukaryotic translation initiation factor 4B) is a 611 amino acid protein that contains one RNA recognition motif ａnd belongs to the eIF4 protein family. Required for proper mRNA/ribosome binding, eIF4B associates with other eIF4 proteins, such as eIF4A, ａnd promotes the ATP-dependent unwinding activity of ｓelect eukaryotic initiation factors. The gene encoding eIF4B maps to human chromosome 12, which encodes over 1,100 genes ａnd comprises approximately 4.5% of the human genome. |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHC |
| WB:1:500~1:2000 More IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
Target Information
| Alternative Names | |
|---|---|
| Tissue Specificity | recommended for detection of Ser 422 phosphorylated eIF4B of m ａnd h origin by WB, IP, IF ａnd IHC(P) |
Database Links
| Entrez Gene | 1975 |
|---|
Application
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Application
Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung carcinoma tissue showing cylasmic localization.
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Application
Western blot analysis of eIF4B phosphorylation expression in untreated (A) ａnd EGF treated (B) HeLa whole cell lysates.
| Application Notes | WB:1:500~1:2000 More IP:1:100~1:500 IF:1:200~1:500 IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
