企業(yè)檔案

Product Name	MAPK8 Antibody
Antibody Type	Primary Antibodies
Product description	JNK1 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, ａnd are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation ａnd development. This kinase is activated by various cell stimuli, ａnd targets specific transcription factors, ａnd thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis ａnd differentiation.1) Deng, Y., et al., Cell 115(1):61-70 (2003). More
Immunogen	This MAPK8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 358-389 amino acids from the C-terminal region of human MAPK8.

Clonality	Polyclonal
Isotype	Ig
Host Species	Rabbit
Tested Applications	IFIHC-PWB
	For WB starting dilution is: 1:1000 For IF starting dilution is: 1:10~50 For IHC-P starting dilution is: 1:10~50:
Species Reactivity	Human
Concentration	1 mg/ml

Gene Symbol	MAPK8
Alternative Names	Mitogen-activated protein kinase 8 MAP kinase 8 MAPK 8 JNK-46 Stress-activated protein kinase 1c SAPK1c Stress-activated protein kinase JNK1 c-Jun N-terminal kinase 1 MAPK8 JNK1 PRKM8 SAPK1 SAPK1C More
Molecular Weight(MW)	48 kDa
Sequence Similarities	Predicted species reactivity based on immunogen sequence: Rat

Entrez Gene	5599
Protein Accession	P45983

Application

MAPK8 Antibody immunohistochemistry analysis in formalin fixed ａnd paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody ａnd DAB staining.
Application

Western blot analysis of anti-JNK1 Pab in HL60 (UV-treated) cell lysate
Application

Confocal immunofluorescent analysis of MAPK8 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-rabbit lgG (green).DAPI was used to stain the cell nuclear (blue).

Application Notes	For WB starting dilution is: 1:1000 For IF starting dilution is: 1:10~50 For IHC-P starting dilution is: 1:10~50:

Form	Liquid
Storage Instructions	Store at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer	Supplied in PBS with 0.09% (W/V) sodium azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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