Maternal embryonic leucine zipper kinase (KIAA0175, HPK38) or MELK, a new member of the Snf1/AMPK family of kinases, encodes a protein with a kinase catalytic domain ａnd a leucine zipper motif consisting of a periodic repetition of leucine residues at every seventh residue located within the N-terminal catalytic domain. This motif has been observed in myriad DNA-binding proteins ａnd is presumed to be involved in protein-DNA interactions, ａnd potentially protein-protein interactions. Research predicts that the gene product of MELK plays a role in the signal transduction events in the egg ａnd early embryo. Mouse ａnd human MELK proteins share 95% sequence identity in the kinase domain ａnd northern blot analysis in mouse indicates that MELK expression is restricted to spermatogonia in the testis ａnd to oocytes in the ovary.
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Recombinant protein

ICC/IFICCIHCFC

Human