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聯(lián)系人：楊燕燕
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技術(shù)文章
PPM1A Antibody (C-term) Catalog Number：OM218459
Product Profile
| Product Name | PPM1A Antibody (C-term) |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WBIHC |
| WB~~1:100~500 IHC~~1:50~100: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Gene Synonyms | |
|---|---|
| Alternative Names | Hide |
| Molecular Weight(MW) | 42448 Da |
| Function | Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 ａnd SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs ａnd termination of the TGF-beta-mediated signaling |
| Tissue Specificity | This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 353~382 amino acids from the C-terminal region of human PPM1A. |
| Cellular Localization | Nucleus. |
Database Links
| Entrez Gene | 5494 |
|---|
Application
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Application
Western blot analysis of anti-PPM1A Pab in mouse kidney tissue lysate (35ug/lane). PPM1A(arrow) was detected using the purified Pab (1:60 dilution).
-
Application
Formalin-fixed ａnd paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Application
Formalin-fixed ａnd paraffin-embedded human colon carcinoma tissue reacted with PPM1A antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
| Application Notes | WB~~1:100~500 IHC~~1:50~100: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high ａnd low pH buffers ａnd neutralized immediately, followed by dialysis against PBS. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
