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技術(shù)文章

PPM1A antibody Catalog Number：OM269347

點(diǎn)擊次數(shù)：32 發(fā)布時(shí)間：2024/9/11 14:01:33
 

Product Profile

Product Name PPM1A antibody
Antibody Type Primary Antibodies
Product description 
Rabbit Polyclonal antibody to PPM1A (protein phosphatase, Mg2+/Mn2+ dependent, 1A)The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, ａnd negatively regulates the activities of, MAP kinases ａnd MAP kinase kinases. It has been shown to inhibit the activation of p38 ａnd JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, ａnd thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest ａnd apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]
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Immunogen 
Recombinant protein encompassing a sequence within the center region of human PPM1A. The exact sequence is proprietary.

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

ICC/IFIHC-PWB
 
*Optimal dilutions/concentrations should be determined by the researcher. :
Species Reactivity

HumanMouseRat
Predicted Reactivity Xenopus laevis, Rabbit, BovineXenopus laevis (89%), Rabbit (99%), Bovine (99%)
Concentration 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification Affinity purified

Target Information

Gene Synonyms
FLJ42306 antibody
MGC9201 antibody
PP2C-ALPHA antibody
PP2CA antibody
PP2Calpha antibody
PPM1A antibody
protein phosphatase 1A (formerly 2C)
magnesium-dependent
alpha isoform antibody
protein phosphatase 1A antibody
protein phosphatase
Mg2+/Mn2+
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Molecular Weight(MW) 42 kDa (note) (3)

Application

  • Application

    Sample (50 ug of whole cell lysate) A: Mouse brain 10% SDS PAGE diluted at 1:1000

  • Application

    Sample (30 ug of whole cell lysate) A: 293T B: A431 10% SDS PAGE diluted at 1:1000

  • Application

    PPM1A antibody detects PPM1A protein at cylasm by immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: PPM1A protein stained by PPM1A antibody diluted at 1:500. Blue: Hoechst 33342 staining.

  • Application

    Immunohistochemical analysis of paraffin-embedded human colon carcinoma, using PPM1A antibody at 1:500 dilution.

  • Application

    Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, ａnd the membrane was blotted with PPM1A antibody diluted at 1:500.

Positive Control 293T , A431 , mouse brain , PC-12 , Rat2
Application Notes
*Optimal dilutions/concentrations should be determined by the researcher. :

Additional Information

Form Liquid
Storage Instructions Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
 

原創(chuàng)作者：上海篤瑪生物科技有限公司

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