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PPM1A antibody Catalog Number：OM269348

點擊次數(shù)：35 發(fā)布時間：2024/9/11 14:00:44
 

Product Profile

Product Name PPM1A antibody
Antibody Type Primary Antibodies
Product description 
Mouse Monoclonal Antibody [7F12] to PPM1AThe protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, ａnd negatively regulates the activities of, MAP kinases ａnd MAP kinase kinases. It has been shown to inhibit the activation of p38 ａnd JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, ａnd thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest ａnd apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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Immunogen 
The immunogen corresponding to a region within amino acids 202 ａnd 382 of human PPM1A expressed in E. Coli.

Key Feature

Clonality Monoclonal
Isotype IgG1
Clone Number 7F12
Host Species Mouse
Tested Applications

ELISAFACSWB
 
ELISA: 1/10000.:
Species Reactivity

HumanMonkey
Concentration 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification  

Target Information

Gene Synonyms
PP2CA
PP2CALPHA
PP2C-ALPHA
Target PPM1A
Molecular Weight(MW) 42.4 kDa (note)

Application

  • Application

    ELISA analysis of control antigen ａnd antigen using PPM1A antibody [7F12].

  • Application

    FACS analysis of HeLa cells using PPM1A antibody [7F12] (green) or a negative control (red).

  • Application

    WB analysis of lysates from (1) untransfected ａnd (2) PPM1A (a.a. 202-382)-hIgGFc transfected HEK293 cells using PPM1A antibody [7F12].

  • Application

    WB analysis of (1) Jurkat, (2) Jurkat, (3) A431, (4) HeLa, (5) HEK293, (6) Raji, (7) MCF-7 ａnd (8) COS7 lysates using PPM1A antibody [7F12].

  • Application

    WB analysis of human PPM1A recombinant protein using PPM1A antibody [7F12].

Application Notes
ELISA: 1/10000.:

Additional Information

Form Liquid
Storage Instructions 4°C; -20°C for long term storage
Storage Buffer Purified antibody in PBS with 0.05% sodium azide ａnd 0.5% protein stabilizer.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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