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技術文章

PPM1A Antibody Catalog Number：OM288632

點擊次數(shù)：26 發(fā)布時間：2024/9/11 13:59:00
 

Product Profile

Product Name PPM1A Antibody
Antibody Type Primary Antibodies
Product description 
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, ａnd negatively regulates the activities of, MAP kinases ａnd MAP kinase kinases. It has been shown to inhibit the activation of p38 ａnd JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, ａnd thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest ａnd apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
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Immunogen 
This PPM1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 355-382 amino acids from human PPM1A.

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WB
 
For WB starting dilution is: 1:1000:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol PPM1A
Alternative Names
Protein phosphatase 1A
Protein phosphatase 2C isoform alpha
PP2C-alpha
Protein phosphatase IA
PPM1A
PPPM1A
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Molecular Weight(MW) 42 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Bovine

Database Links

Entrez Gene 5494
Protein Accession P35813

Application

  • Application

    Western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstratesdetected the PPM1A protein (arrow).

Application Notes
For WB starting dilution is: 1:1000:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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