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技術(shù)文章

GluR2 antibody Catalog Number：OM254733

點(diǎn)擊次數(shù)：23 發(fā)布時間：2024/9/11 13:49:17
 

Product Profile

Product Name GluR2 antibody
Antibody Type Primary Antibodies
Product description 
Rabbit Polyclonal antibody to GluR2Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain ａnd are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), ａnd function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human ａnd animal studies suggest that pre-mRNA editing is essential for brain function, ａnd defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip ａnd flop isoforms that vary in their signal transduction properties), has been no
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Immunogen 
A synthesized peptide derived from human GluR2

Key Feature

Clonality Polyclonal
Isotype IgG
Host Species Rabbit
Tested Applications

IHCWB
 
WB 1:500-1:2000, IHC 1:50-1:200:
Species Reactivity

HumanMouseRat
Concentration 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification Affinity purified

Target Information

Gene Synonyms
glutamate receptor
ionotropic
AMPA 2
HBGR2
GluR-K2
GRIA2
GLURB
GluA2
GLUR2
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Target GluR2
Tissue Specificity GRIA2

Application

  • Application

    Western blot analysis of GluR2 expression in Mouse braintissue lysates,The lane on the left is treated with the antigen-specific peptide.

Application Notes
WB 1:500-1:2000, IHC 1:50-1:200:

Additional Information

Form Liquid
Storage Instructions Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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