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GluR2 Antibody Catalog Number：OM279910

點擊次數(shù)：20 發(fā)布時間：2024/9/11 13:44:20
 

Product Profile

Product Name GluR2 Antibody
Antibody Type Primary Antibodies
Product description 
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) ａnd they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann ａnd Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003)1) Chung HJ, Steinberg JP, Huganir RL, Linden DJ (2003) Requirement of AMPA receptor GluR2 phosphorylation for cerebellar long-term depression. Science 300:1751-1755.
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Immunogen 
Peptide corresponding to amino acid residues from rat GluR2, conjugated to keyhole limpet hemocyanin (KLH).

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

WB
 
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse, non-human primates ａnd zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity

Zebra Fish
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol Gria2
Alternative Names
GluA2
GluR2
gluR-B
GluR-K2
Glur2
AMPA-selective glutamate receptor 2
GluR-2
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Molecular Weight(MW) 100

Database Links

Entrez Gene 29627
Protein Accession P19491

Application

  • Application

    Western blot of a rat hippocampal (Hipp) lysate showing the specific immunolabeling of the ~100k GluR2 protein.

Application Notes
The antibody has been directly tested for reactivity in Western blots with human tissue. It is anticipated that the antibody will also react with chicken, human, mouse, non-human primates ａnd zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information

Form Liquid
Storage Instructions GluR2 antibody can be stored at -20˚C ａnd is stable at -20˚C for at least 1 year.
Storage Buffer 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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