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GRIA2 [A3-A7] Catalog Number：OM627371

點(diǎn)擊次數(shù)：19 發(fā)布時間：2024/9/11 13:36:31
 

Product Profile

Product Name GRIA2 [A3-A7]
Antibody Type Primary Antibodies
Product description 
Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system ａnd plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, ａnd thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly ａnd enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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Immunogen 
Recombinant protein

Key Feature

Clonality Monoclonal
Isotype IgG2b
Host Species Mouse
Tested Applications

WBIHCFC
 
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100
Species Reactivity

Human
Concentration 2 mg/mL.

Target Information

Alternative Names
AMPA 2 antibody AMPA selective glutamate receptor 2 antibody AMPA-selective glutamate receptor 2 antibody AMPA2 antibody GluA2 antibody GLUR 2 antibody GLUR B antibody GluR K2 antibody GluR-2 antibody GluR-B antibody GluR-K2 antibody GLUR2 antibody GLURB antibody Glutamate receptor 2 antibody Glutamate receptor ionotropic AMPA 2 antibody Glutamate receptor ionotropic antibody Gria2 antibody GRIA2_HUMAN antibody HBGR2 antibody
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Molecular Weight(MW) 99 kDa
Cellular Localization Cell membrane. Endoplasmic reticulum membrane

Database Links

SwissProt ID P42262

Application

  • Application

    Fig1: Western blot analysis of Glutamate receptor 2 on human GRIA2 recombinant protein using anti- Glutamate receptor 2 antibody at 1/1,000 dilution.

  • Application

    Fig2: Western blot analysis of Glutamate receptor 2 on HEK293 (1) ａnd Glutamate receptor 2-hIgGFc transfected HEK293 (2) cell lysate using anti- Glutamate receptor 2 antibody at 1/1,000 dilution.

  • Application

    Fig3: Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using anti- Glutamate receptor 2 antibody. Counter stained with hematoxylin.

  • Application

    Fig4: Flow cytometric analysis of SK-N-SH cells with Glutamate receptor 2 antibody at 1/100 dilution (green) compared with an unlabelled control (cells without incubation with primary antibody; red).

Positive Control Human Glutamate receptor 2 recombinant protein, Glutamate receptor 2-hIgGFc transfected HEK293 cell lysate, human rectum cancer tissues, SK-N-SH.
Application Notes
WB:1:500-1:2,000
IHC:1:50-1:200
FC:1:50-1:100

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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