WB~~1:100~500:

Csnk2a2
Casein kinase II subunit alpha＇

Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis ａnd transcription, as well as viral infection. May act as a regulatory node which integrates ａnd coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity ａnd G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating ＇Ser-392＇ of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis Phosphorylates the caspases CASP9 ａnd CASP2 ａnd the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage ａnd activation by CASP8, ａnd inhibits the dimerization of CASP2 ａnd activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III ａnd IV. Also phosphorylates ａnd regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC ａnd MYB. Phosphorylates Hsp90 ａnd its co-chaperones FKBP4 ａnd CDC37, which is essential for chaperone function Regulates Wnt signaling by phosphorylating CTNNB1 ａnd the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins (By similarity)

WB~~1:100~500: