企業(yè)檔案
- 會(huì)員類型：免費(fèi)會(huì)員
- 工商認(rèn)證： 【已認(rèn)證】
- 最后認(rèn)證時(shí)間：
- 法人：
- 注冊(cè)號(hào)：
- 企業(yè)類型：生產(chǎn)商
- 注冊(cè)資金：人民幣萬(wàn)
聯(lián)系我們
聯(lián)系人：楊燕燕
熱門(mén)標(biāo)簽
技術(shù)文章
DKK3 Antibody Catalog Number：OM231341
點(diǎn)擊次數(shù)：30 發(fā)布時(shí)間：2024/9/4 13:55:35
Product Profile
| Product Name | DKK3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
Key Feature
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Clone Number | 4G7 |
| Host Species | Mouse |
| Tested Applications | WBFC |
| WB~~1:500 - 2000. FC~~1:200 - 400.: | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification |
Target Information
| Gene Synonyms | |
|---|---|
| Alternative Names | |
| Molecular Weight(MW) | 38390 Da |
| Function | Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt ａnd by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero- posterior axial patterning, limb development, somitogenesis ａnd eye formation. In the adult, Dkks are implicated in bone formation ａnd bone disease, cancer ａnd Alzheimer disease (By similarity) More |
| Tissue Specificity | Highest expression in heart, brain, ａnd spinal cord |
| Cellular Localization | Secreted. |
Database Links
| Entrez Gene | 27122 |
|---|---|
| Nucleotide Accession | NP_056965.3 |
Application
-
Application
Figure 1: Western blot analysis using DKK3 mouse mAb against HEK293 (1), MCF-7 (2) ａnd HL7702 (3) cell lysate.
-
Application
Figure 2: Flow cytometric analysis of MCF-7 cells using anti-DKK3 mAb (green) ａnd negative control (purple).
| Application Notes | WB~~1:500 - 2000. FC~~1:200 - 400.: |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | Purified recombinant fragment of human DKK3 expressed in E. Coli. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
