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DKK3 [C6-A5] Catalog Number：OM627641

點擊次數(shù)：31 發(fā)布時間：2024/9/4 13:49:38
 

Product Profile

Product Name DKK3 [C6-A5]
Antibody Type Primary Antibodies
Product description 
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt ａnd by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis ａnd eye formation. In the adult, Dkks are implicated in bone formation ａnd bone disease, cancer ａnd Alzheimer disease.
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Immunogen 
Recombinant protein

Key Feature

Clonality Monoclonal
Isotype IgG1
Host Species Mouse
Tested Applications

WBIHC
 
WB:1:250~1:1000
IHC:1:20~1:100
Notes:Optimal dilutions/concentrations should be determined by the researcher.
Species Reactivity

Human
Concentration 2 mg/mL.

Target Information

Alternative Names
Dickkopf 3 antibody Dickkopf 3 homolog (Xenopus laevis) antibody Dickkopf 3 homolog antibody Dickkopf homolog 3 antibody Dickkopf related protein 3 antibody Dickkopf related protein 3 Precursor antibody Dickkopf WNT signaling pathway inhibitor 3 antibody Dickkopf
Xenopus
homolog of
3 antibody Dickkopf-3 antibody Dickkopf-related protein 3 antibody Dickkopf3 antibody DKK 3 antibody Dkk-3 antibody DKK3 antibody DKK3_HUMAN antibody hDkk 3 antibody hDkk-3 antibody hDkk3 antibody Regulated in glioma antibody REIC antibody RIG antibody RIG-like 5-6 antibody RIG-like 7-1 antibody
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Molecular Weight(MW) 38 kDa
Cellular Localization Secreted.

Database Links

SwissProt ID Q9UBP4

Application

  • Application

    Fig1: Western blot analysis of DKK3 on human DKK3 recombinant protein using anti-DKK3 antibody at 1/1,000 dilution.

  • Application

    Fig2: Western blot analysis of DKK3 on HEK293 (1) ａnd DKK3-hIgGFc transfected HEK293 (2) cell lysate using anti-DKK3 antibody at 1/1,000 dilution.

  • Application

    Fig3: Immunohistochemical analysis of paraffin-embedded human brain tissue using anti-DKK3 antibody. Counter stained with hematoxylin.

Positive Control Human DKK3 recombinant protein, DKK3-hIgGFc transfected HEK293 cell lysate, human brain tissue.
Application Notes
WB:1:250~1:1000
IHC:1:20~1:100
Notes:Optimal dilutions/concentrations should be determined by the researcher.

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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