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技術(shù)文章

WHSC2 Antibody Catalog Number：OM295133

點(diǎn)擊次數(shù)：20 發(fā)布時(shí)間：2024/9/2 14:05:14
 

Product Profile

Product Name WHSC2 Antibody
Antibody Type Primary Antibodies
Product description 
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, ａnd may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted ａnd tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.1) Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
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Immunogen 
This WHSC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 251-279 amino acids from the Central region of human WHSC2.

Key Feature

Clonality Polyclonal
Isotype Ig
Host Species Rabbit
Tested Applications

WB
 
For WB starting dilution is: 1:1000:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol NELFA
Alternative Names
Negative elongation factor A
NELF-A
Wolf-Hirschhorn syndrome candidate 2 protein
NELFA
WHSC2
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Molecular Weight(MW) 57 kDa
Sequence Similarities Predicted species reactivity based on immunogen sequence: Mouse

Database Links

Entrez Gene 7469
Protein Accession Q9H3P2

Application

  • Application

    Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

Application Notes
For WB starting dilution is: 1:1000:

Additional Information

Form Liquid
Storage Instructions Store at 4˚C for three months ａnd -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Storage Buffer Supplied in PBS with 0.09% (W/V) sodium azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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