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NLRP3 [SC06-23] Catalog Number：OM627352

點(diǎn)擊次數(shù)：38 發(fā)布時(shí)間：2024/8/30 15:13:14
  

Product Profile

Product Name NLRP3 [SC06-23]
Antibody Type Primary Antibodies
Product description 
Cryopyrin interacts selectively with apoptosis-associated specklike protein containing a CARD domain (ASC). This complex may function as an upstream activator of NFkB signaling ａnd caspase-1 activation. The complex also inhibits TNFa induced activation ａnd nuclear translocation of RelA/NFkB p65. Mutations in Cryopyrin ａnd Pyrin proteins are responsible for several autoinflammatory disorders in humans, including familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) ａnd chronic infantile neurologic cutaneous ａnd articular syndrome (CINCA).
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Immunogen 
recombinant protein

Key Feature

Clonality Monoclonal
Isotype IgG
Host Species Recombinant rabbit
Tested Applications

WBICC/IFIHCIPFC
 
WB:1:1,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100
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Species Reactivity

HumanMouseRat
Concentration 1 mg/mL.

Target Information

Alternative Names
AGTAVPRL antibody AII/AVP antibody
Angiotensin/vasopressin receptor AII/AVP like antibody
Angiotensin/vasopressin receptor AII/AVP-like antibody
C1orf7 antibody
Caterpiller protein 1.1 antibody
CIAS 1 antibody
CIAS1 antibody
CLR1.1 antibody
Cold autoinflammatory syndrome 1 antibody
Cold autoinflammatory syndrome 1 protein antibody
Cryopyrin antibody
Familial cold autoinflammatory syndrome antibody
FCAS antibody
FCU antibody
LRR ａnd PYD domains-containing protein 3 antibody
Muckle-Wells syndrome antibody
MWS antibody
NACHT antibody
NACHT LRR ａnd PYD containing protein 3 antibody
NALP 3 antibody
NALP3 antibody
NALP3_HUMAN antibody
NLRP3 antibody
PYPAF 1 antibody
PYPAF1 antibody
PYRIN containing APAF1 like protein 1 antibody
PYRIN-containing APAF1-like protein 1 antibody
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Molecular Weight(MW) 118/85 kDa
Cellular Localization Cylasm, Inflammasome, Secreted, Nucleus, Endoplasmic reticulum.

Database Links

SwissProt ID Q96P20
Q8R4B8
287362

Application

  • Application

    Fig1: Western blot analysis of NLRP3 on human lung tissue lysates. Proteins were transferred to a PVDF membrane ａnd blocked with 5% BSA in PBS for 1 hour at room temperature. The primary antibody (ET1610-93, 1/500) was used in 5% BSA at room temperature for 2 hours. Goat Anti-Mouse IgG - HRP Secondary Antibody (HA1006) at 1:5,000 dilution was used for 1 hour at room temperature.

  • Application

    Fig2: ICC staining NLRP3 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig3: ICC staining NLRP3 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig4: ICC staining NLRP3 in PMVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig5: Immunohistochemical analysis of paraffin-embedded mouse bladder tissue using anti- NLRP3 antibody. Counter stained with hematoxylin.

  • Application

    Fig6: Immunohistochemical analysis of paraffin-embedded mouse spleen tissue using anti- NLRP3 antibody. Counter stained with hematoxylin.

  • Application

    Fig7: Flow cytometric analysis of Jurkat cells with NLRP3 antibody at 1/50 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.

Positive Control Human lung tissue lysates, Hela, HUVEC, PMVEC, mouse bladder tissue, mouse spleen tissue.
Application Notes
WB:1:1,000
ICC:1:100-1:500
IHC:1:50-1:200
FC:1:50-1:100
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Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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