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GRP78 BiP [2-7] Catalog Number：OM638616

點(diǎn)擊次數(shù)：19 發(fā)布時(shí)間：2024/8/30 14:54:47
  

Product Profile

Product Name GRP78 BiP [2-7]
Antibody Type Primary Antibodies
Product description 
Binding immunoglobulin protein (BiP) also known as 78 kDa glucose-regulated protein (GRP-78) or heat shock 70 kDa protein 5 (HSPA5) is a protein that in humans is encoded by the HSPA5 gene. BiP is a HSP70 molecular chaperone located in the lumen of the endoplasmic reticulum (ER) that binds newly synthesized proteins as they are translocated into the ER, ａnd maintains them in a state competent for subsequent folding ａnd oligomerization. BiP is also an essential component of the translocation machinery, as well as playing a role in retrograde transport across the ER membrane of aberrant proteins destined for degradation by the proteasome. Like many stress ａnd heat shock proteins, BiP/GRP78 has potent immunological activity when released from the internal environment of the cell into the extracelluar space.specifically, it feeds anti-inflammatory ａnd pro-resolutory signals into immune networks, thus helping to resolve inflammation.
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Immunogen 
peptide

Key Feature

Clonality Monoclonal
Isotype IgG1
Host Species Mouse
Tested Applications

WBICCIHC
 
WB:1:5,000-1:10,000
ICC:1:200
Species Reactivity

Human
Concentration 2 mg/mL.

Target Information

Alternative Names
78 kDa glucose regulated protein antibody
78 kDa glucose-regulated protein antibody
AL022860 antibody
AU019543 antibody
BIP antibody
D2Wsu141e antibody
D2Wsu17e antibody
Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78 antibody
Endoplasmic reticulum lumenal Ca2+ binding protein grp78 antibody
Epididymis secretory sperm binding protein Li 89n antibody
FLJ26106 antibody
Glucose Regulated Protein 78kDa antibody
GRP 78 antibody
GRP-78 antibody
GRP78 antibody
GRP78_HUMAN antibody
Heat shock 70 kDa protein 5 antibody
Heat Shock 70kDa Protein 5 antibody
Heat shock protein family A (Hsp70) member 5 antibody
HEL S 89n antibody
Hsce70 antibody
HSPA 5 antibody
HSPA5 antibody
Immunoglobulin Heavy Chain Binding Protein antibody
Immunoglobulin heavy chain-binding protein antibody
mBiP antibody
MIF2 antibody
Sez7 antibody
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Molecular Weight(MW) 78kDa
Cellular Localization Cylasm, endoplasmic reticulum lumen

Database Links

SwissProt ID P11021

Application

  • Application

    Fig1: Western blot analysis on human spermatozoa lysates using anti- GRP78 mouse mAb.

  • Application

    Fig2: ICC staining GRP78 in Hela cells (red). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

  • Application

    Fig3: Western blot analysis of GRP78 on hybrid fish (crucian-carp) heart tissue lysate using anti-GRP78 antibody at 1/500 dilution.

Positive Control Hela, human spermatozoa
Application Notes
WB:1:5,000-1:10,000
ICC:1:200

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 0.5%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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