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FLT3 Antibody Catalog Number：OM278969

點(diǎn)擊次數(shù)：17 發(fā)布時(shí)間：2024/8/26 13:41:27
 

Product Profile

Product Name FLT3 Antibody
Antibody Type Primary Antibodies
Product description 
FLT3 encodes a class III receptor tyrosine kinase that regulates hemaoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, ａnd a cylasmic kinase domain split into two parts by a kinase-ｉnsert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to auhosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates ａnd activates multiple cylasmic effector molecules in pathways involved in apoptosis, proliferation, ａnd differentiation of hemaoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia ａnd acute lymphoblastic leukemia.1) Sekine S et, al. (2008) J Immunol. ;180 (12): 8126-34Pratz K et, al. (2008) Leuk Lymphoma. 2008 ;49 (5): 852-63. Al Shaer L et, al. (2008) Br J Haematol. 141 (4): 483-93.
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Immunogen 
FLT3 (Ab-591) antibody was raised against a peptide sequence around aa.589~593 (Y-F-Y-V-D) derived from Human FLT3.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IFWB
 
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol FLT3
Alternative Names
FLK2
STK1
CD135
FLK-2
CDKN6
FLT-3
FLT3
STK-1
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Molecular Weight(MW) 130, 160 kDa
Tissue Specificity This antibody detects endogenous level of total FLT3 protein.

Database Links

Entrez Gene 2322
Protein Accession NP_004110.2

Application

  • Application

    Immunofluorescence staining of methanol-fixed HeLa cells using FLT3 (Ab-591).

  • Application

    Western blot analysis of lysed extracts from 293 ａnd MCF cells using FLT3 (Ab-591).

Application Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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