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BRCA1 [D2-C6] Catalog Number：OM627809

點(diǎn)擊次數(shù)：33 發(fā)布時(shí)間：2024/8/23 13:55:40
 

Product Profile

Product Name BRCA1 [D2-C6]
Antibody Type Primary Antibodies
Product description 
In 1990, a breast cancer susceptibility gene, designated BRCA1, was localized to chromosome 17q. Mutations within this gene are believed to account for approximately 45% of families with high incidence of breast cancer ａnd at least 80% of families with increased incidence of both early-onset breast cancer ａnd ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer but, unlike BRCA1, does not confer a substantially elevated risk of ovarian cancer. The BRCA1 gene is expressed in numerous tissues, including breast ａnd ovary, ａnd encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino terminal region, but is otherwise unrelated to any previously described proteins. Like many other genes involved in familial cancer, BRCA1 appears to encode a tumor suppressor, a protein that acts as a negative regulator of tumor growth.
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Immunogen 
Recombinant protein

Key Feature

Clonality Monoclonal
Isotype IgG1
Host Species Mouse
Tested Applications

WBIHC
 
WB:1:500-1:1,000
IHC:1:100-1:500
Species Reactivity

Human
Concentration 2 mg/mL.

Target Information

Alternative Names
BRCA 1 antibody BRCA1 antibody BRCA1 DNA repair associated antibody BRCA1/BRCA2 containing complex subunit 1 antibody BRCA1/BRCA2-containing complex
subunit 1 antibody BRCA1_HUMAN antibody BRCAI antibody BRCC 1 antibody BRCC1 antibody Breast ａnd ovarian cancer susceptibility protein 1 antibody Breast Cancer 1 antibody Breast Cancer 1 Early Onset antibody Breast cancer type 1 susceptibility protein antibody BROVCA1 antibody FANCS antibody IRIS antibody PNCA4 antibody PPP1R53 antibody Protein phosphatase 1 regulatory subunit 53 antibody PSCP antibody RING finger protein 53 antibody RNF53 antibody
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Molecular Weight(MW) 208 kDa
Cellular Localization Cylasm. Nucleus. Plasma Membrane.

Database Links

SwissProt ID P38398

Application

  • Application

    Fig1: Western blot analysis of BRCA1 on human BRCA1 recombinant protein using anti-BRCA1 antibody at 1/1,000 dilution.

  • Application

    Fig2: Western blot analysis of BRCA1 on HEK293 (1) ａnd BRCA1-hIgGFc transfected HEK293 (2) cell lysate using anti-BRCA1 antibody at 1/1,000 dilution.

  • Application

    Fig3: Immunohistochemical analysis of paraffin-embedded human esophagus cancer tissue using anti-BRCA1 antibody. Counter stained with hematoxylin.

  • Application

    Fig4:Immunohistochemical analysis of paraffin-embedded human esophagus tissue using anti-BRCA1 antibody. Counter stained with hematoxylin.

Positive Control Human BRCA1 recombinant protein, BRCA1-hIgGFc transfected HEK293 cell lysate, human esophagus cancer tissue, human esophagus tissue.
Application Notes
WB:1:500-1:1,000
IHC:1:100-1:500

Additional Information

Form Liquid
Storage Instructions Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage Buffer 1*TBS (pH7.4), 1%BSA, Preservative: 0.05% Sodium Azide.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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