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技術(shù)文章

BRCA1 (phospho Ser1524) antibody Catalog Number：OM241903

點擊次數(shù)：29 發(fā)布時間：2024/8/23 13:49:42
 

Product Profile

Product Name BRCA1 (phospho Ser1524) antibody
Antibody Type Primary Antibodies
Product description 
Rabbit Polyclonal antibody to BRCA1 (Phospho Ser1524)The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation
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Immunogen 
Peptide sequence around phosphorylation site of serine 1524 (Y-P-S(p)-Q-E) derived from Human BRCA1.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHC-P
 
Suggested starting dilutions are as follows. IHC-P: 1:50~1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:
Species Reactivity

Human
Concentration 1 mg/ml (Please refer to the vial label for the specific concentration)
Purification Affinity purified

Target Information

Gene Synonyms
BRCAI
BRCC1
BROVCA1
IRIS
PNCA4
PSCP
RNF53
BRCA1
breast cancer type 1 susceptibility protein
RING finger protein 53
breast ａnd ovarian cancer sususceptibility protein 1
breast ａnd ovarian cancer susceptibility protein 1
protein phosphatase 1
re
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Target BRCA1 (Phospho Ser1524)
Molecular Weight(MW) 220 (note)

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BRCA1(Phospho-Ser1524) Antibody (left) or the same antibody preincubated with blocking peptide (right)

Application Notes
Suggested starting dilutions are as follows. IHC-P: 1:50~1:100. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.:

Additional Information

Form Liquid
Storage Instructions Keep as concentrated solution. Aliquot ａnd store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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