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聯(lián)系人：楊燕燕
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技術(shù)文章
Anti-BRCA1 antibody Catalog Number：OM642668
點(diǎn)擊次數(shù)：24 發(fā)布時(shí)間：2024/8/23 13:12:29
Product Profile
| Product Name | Anti-BRCA1 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAICC/IFIHC |
| IHC:1:200-1:2000 ICC/IF:1:100-1:500 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | BRCA1 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | BRCA1 DNA repair associated |
| Gene Summary | This gene encodes a 190 kD nuclear phosphoprotein that plays a role in maintaining genomic stability, ａnd it also acts as a tumor suppressor. The BRCA1 gene contains 22 exons spanning about 110 kb of DNA. The encoded protein combines with other tumor suppressors, DNA damage sensors, ａnd signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, ａnd through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, ａnd recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers ａnd more than 80% of inherited breast ａnd ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization ａnd physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2020] More |
| Molecular Weight(MW) | 208KD |
| Cellular Localization | Chromosome, Cylasm, Nucleus |
Application
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IHC
Immunohistochemical analysis of paraffin-em
bedded renal carcinoma tissues using BRCA1 antibody with DAB staining. -
IHC
Immunohistochemical analysis of paraffin-em
bedded bladder cancer tissues using BRCA1 antibody with DAB staining. -
ICC/IF
Immunofluorescence analysis of Hela cells using BRCA1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin.
| Application Notes | IHC:1:200-1:2000 ICC/IF:1:100-1:500 |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
