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聯(lián)系人：楊燕燕
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技術(shù)文章
Rabbit anti-BRCA1 polyclonal antibody - N-terminal region Catalog Number：OM105180
點(diǎn)擊次數(shù)：21 發(fā)布時(shí)間：2024/8/23 11:59:17
Product Profile
| Product Name | Rabbit anti-BRCA1 polyclonal antibody - N-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-BRCA1 antibody: synthetic peptide directed towards the N terminal of human BRCA1 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | DogHumanRat |
| Concentration | 1 mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | BRCA1 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | Breast cancer 1, early onset |
| Gene Summary | The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. BRCA1 acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. BRCA1 plays a central role in DNA repair by facilitating cellular response to DNA repair. BRCA1 is required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. BRCA1 is involved in transcriptional regulation of P21 in response to DNA damage. BRCA1 is also required for FANCD2 targeting to sites of DNA damage.It may function as a transcriptional regulator. BRCA1 inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation. More |
| Alternative Names | More |
| Molecular Weight(MW) | 76kDa |
| Sequence | 680 amino acids |
Database Links
| Entrez Gene | 672 |
|---|---|
| SwissProt ID | P38398 |
| Protein Accession | NP_009229 |
Application
-
Western blot
0.2-1 ug/ml
ELISA Titer: 1:1562500
Positive Control: ACHN cell lysate
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot ａnd store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
