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技術(shù)文章

BRCA1 Antibody Catalog Number：OM272678

點(diǎn)擊次數(shù)：24 發(fā)布時(shí)間：2024/8/23 11:57:30
 

Product Profile

Product Name BRCA1 Antibody
Antibody Type Primary Antibodies
Product description 
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation1) Lin SY, et al. (2004) Proc Natl Acad Sci U S A, 101 (17): 6484-6489Zhang J, et al. (2004) Mol Cell Biol; 24 (2): 708-718Beger C, et al. (2001) Proc Natl Acad Sci U S A; 98 (1): 130-135Gardner K, et al. (2001) Breast Cancer Res; 3 (1): 11-13Zheng L, et al. (2001) Proc Natl Acad Sci U S A; 98 (17): 9587-9592
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Immunogen 
BRCA1 (Ab-1524) antibody was raised against a peptide sequence around aa.1522~1526 (Y-P-S-Q-E) derived from Human BRCA1.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IFWB
 
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol BRCA1
Alternative Names
IRIS
PSCP
BRCAI
BRCC1
PNCA4
RNF53
BROVCA1
PPP1R53
ASK1
MAPKKK5
MEKK5
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Molecular Weight(MW) 220 kDa
Tissue Specificity This antibody detects endogenous level of total BRCA1 protein.

Database Links

Entrez Gene 672
Protein Accession NP_009225.1

Application

  • Application

    Western blot analysis of lysed extracts from 293 ａnd MCF cells using BRCA1 (Ab-1524).

  • Application

    Immunofluorescence staining of methanol-fixed HeLa cells using BRCA1 (Ab-1524).

Application Notes
Western Blot: 1:500~1:1000, Immunofluorescence: 1:100~1:200:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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