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技術(shù)文章

BRCA1 (phospho Ser1423) Antibody Catalog Number：OM272679

點(diǎn)擊次數(shù)：23 發(fā)布時(shí)間：2024/8/23 11:56:46
 

Product Profile

Product Name BRCA1 (phospho Ser1423) Antibody
Antibody Type Primary Antibodies
Product description 
The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination ａnd transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase ａnd the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA ａnd preventing its dephosphorylation1) Kim ST, et al. (2002) Genes Dev; 16 (5): 560-570Arlt MF, et al. (2004) Mol Cell Biol; 24 (15): 6701-6709Zhang J, et al. (2004) Mol Cell Biol; 24 (2): 708-718Greenberg RA, et al. (2006) Genes Dev; 20 (1): 34-46Tibbetts RS, et al. (2000) Genes Dev; 14 (23): 2989-3002
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Immunogen 
BRCA1 (Phospho-Ser1423) antibody was raised against a peptide sequence around phosphorylation site of serine 1423 (H-G-S (p) -Q-P) derived from Human BRCA1.

Key Feature

Clonality Polyclonal
Host Species Rabbit
Tested Applications

IHCWB
 
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol BRCA1
Alternative Names
IRIS
PSCP
BRCAI
BRCC1
PNCA4
RNF53
BROVCA1
PPP1R53
ERYF1
GF1
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Molecular Weight(MW) 220 kDa
Tissue Specificity This antibody detects endogenous level of BRCA1 only when phosphorylated at serine 1423.

Database Links

Entrez Gene 672
Protein Accession NP_009225.1

Application

  • Application

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using BRCA1 (Phospho-Ser1423).

  • Application

    Western blot analysis of lysed extracts from HT29 cells untreated or treated with Anisomycin using BRCA1 (Phospho-Ser1423).

Application Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:

Additional Information

Form Liquid
Storage Instructions Store antibody at -20˚C for up to one year.
Storage Buffer Antibody supplied in phosphate buffered saline (without Mg2+ ａnd Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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