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技術(shù)文章

BRCA1 Antibody Catalog Number：OM272682

點(diǎn)擊次數(shù)：26 發(fā)布時(shí)間：2024/8/23 11:50:18
 

Product Profile

Product Name BRCA1 Antibody
Antibody Type Primary Antibodies
Product description 
BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer ａnd more than 80% of inherited breast ａnd ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, ａnd an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression.1) Mark, W.Y., et al., (2005) J. Mol. Biol. 345 (2), 275-287.
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Immunogen 
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human BRCA1.

Key Feature

Clonality Polyclonal
Isotype Cocktail
Host Species Rabbit
Tested Applications

ELISAIHCWB
 
WB:1:500~1:2000
IHC:1:50~1:200
Species Reactivity

Human
Concentration 1 mg/ml
Purification Affinity purified

Target Information

Gene Symbol BRCA1
Alternative Names
BRCA1
IRIS
PSCP
BRCAI
BRCC1
PNCA4
RNF53
BROVCA1
PPP1R53
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Molecular Weight(MW) 76 kDa, 208 kDa, 208 kDa, 208 kDa, 181 kDa, 178 kDa, 166 kDa, 203 kDa, 81 kDa, 85 kDa, 81 kDa, 7 kDa

Database Links

Entrez Gene 672
Protein Accession NP_009229

Application

  • Application

    Antibody used in IHC on Human Muscle.

  • Application

    Antibody used in WB on Human K562 at 0.5-1 ug/ml.

Positive Control 1) Cat. No. 1204 - K562 Cell Lysate
Application Notes
WB:1:500~1:2000
IHC:1:50~1:200

Additional Information

Form Liquid
Storage Instructions For short periods of storage (days) store at 4˚C. For longer periods of storage, store BRCA1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer Antibody is lyophilized in PBS buffer with 2% sucrose.. Final antibody concentration is 1 mg/mL.

原創(chuàng)作者：上海篤瑪生物科技有限公司

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