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聯(lián)系人：楊燕燕
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技術(shù)文章
Anti-TLR4 antibody Catalog Number：OM641714
點(diǎn)擊次數(shù)：18 發(fā)布時(shí)間：2024/8/21 13:33:51
Product Profile
| Product Name | Anti-TLR4 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC |
| IHC:1:200-1:1000 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1 mg/ml |
| Purification | Protein A |
Target Information
| Gene Symbol | TLR4 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | toll like receptor 4 |
| Gene Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition ａnd activation of innate immunity. TLRs are highly conserved from Drosophila to humans ａnd share structural ａnd functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, ａnd mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, ａnd with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020] More |
| Source | Rabbit |
| Cellular Localization | Plasma membrane; Endosome |
Application
-
IHC
Immunohistochemical analysis of paraffin-em
bedded rectal cancer tissues using TLR4 antibody with DAB staining -
IHC
Immunohistochemical analysis of paraffin-em
bedded ovarian cancer tissues using TLR4 antibody with DAB staining.
| Application Notes | IHC:1:200-1:1000 |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
