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聯(lián)系人：楊燕燕
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技術(shù)文章
Rabbit anti-TLR4 polyclonal antibody - C-terminal region Catalog Number：OM117923
點擊次數(shù)：16 發(fā)布時間：2024/8/21 13:30:15
Product Profile
| Product Name | Rabbit anti-TLR4 polyclonal antibody - C-terminal region |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | The immunogen for anti-TLR4 antibody: synthetic peptide directed towards the C terminal of human TLR4 |
Key Feature
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. | |
| Species Reactivity | Human |
| Concentration | 1 mg/ml |
| Purification | Affinity purified |
Target Information
| Gene Symbol | TLR4 |
|---|---|
| Gene Synonyms | More |
| Gene Full Name | Toll-like receptor 4 |
| Gene Summary | The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition ａnd activation of innate immunity. TLRs are highly conserved from Drosophila to humans ａnd share structural ａnd functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, ａnd mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, ａnd in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. More |
| Alternative Names | More |
| Molecular Weight(MW) | 93kDa |
| Sequence | 839 amino acids |
Database Links
| Entrez Gene | 7099 |
|---|---|
| SwissProt ID | O00206 |
| Protein Accession | NP_612564 |
Application
-
Immunoblot
Lane 1: Untreated human U251 cell lysate
Lane 2: IL-1beta treated human U251 cell lysate
Primary Antibody Dilution:
1:500
Secondary Antibody:
Anti-rabbit-HRP
Secondary Antibody Dilution:
1:500
Gene Name:
TLR4
Submitted by:
Anonymous -
Western blot
0.2-1 ug/ml
ELISA Titer: 1:312500
Positive Control: A549 cell lysate
| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
Additional Information
| Form | Liquid |
|---|---|
| Storage Instructions | Aliquot ａnd store at -20°C. Avoid repeated freeze / thaw cycles |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide ａnd 50% glycerol. |
原創(chuàng)作者：上海篤瑪生物科技有限公司
